comparable to NSAIDs and are used therapeutically in OA, RA, acute pain andprimary dysmenorrhea. These compounds produce less GI ulceration and hemorrhage than NSAIDs due to their COX-2 selectivity. Also they do not inhibit platelet aggregation and have minimal renal and CV side effects. These drugs should not be used in 3rd trimester of pregnancy since they promote closure of ductus arteriosus.…
Adverse Effects: upset stomach; vomiting; stomach pain; belching; constipation; dry mouth; increased urination; loss of appetite; metallic taste…
What major side effects of his antibiotic should you monitor K.D. for? While a patient is taking Trimethoprim Sulfamethoxazole you should monitor for an allergic reaction aka angioedema (swelling that occurs in the face/tongue/throat). It can also cause nausea, diarrhea, loss of appetite and diarrhea, myasthenia, changes in cognitive status, mood swings, kidney problems monitored by UO and blood in the urine, extreme lethargy, hypoglycemia. More serious side effects include persistent headache, muscle stiffness in patient’s neck, dysrhythmia, or seizures. Rare allergic reactions and more severe side effects of taking this medication may include Steven-Johnsons syndrome (peeling rash, blisters, itching), agranulocytosis (low WBC count, sore throat, fever), aplastic anemia (bruises or bleeding that is caused easily, and liver (yellowing of the eyes, dark urine) or lung injury. It can also cause clostridium difficile associated diarrhea which is caused by a type resistant bacteria. Manifestations of this include diarrhea, abdominal pain, or hematochezia. If this medication is used over a longer period of time it can cause thrush or a yeast…
* ADVERSE EFFECTSAdverse effects of nifedipiine are generally minor and are related to vasodilation such as headache, dizziness, peripheral edema, and flushing. Immediate-acting forms of nifedipine can cause reflex tachycardia. To avoid rebound hypotension, the drug should be discontinued gradually. In rare cases, nifedipine may cause a paradoxical increase in anginal pain, possibly related to hypotension or heart failure.Contraindications: the only contraindication is prior hypersensitivity to nifedipine.INTERACTIONSDrug- Drug: when given concurrently, other antihypertensives have additive effects with nifedipine on blood pressure. Concurrent use of nifedipine with a beta blocker increases the risk of congestive heart failure. Nifedipine may increase serum levels of digoxin, leading to bradycardia and digoxin toxicity. Alcohol potentiates the vasodilating…
Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not…
American Pain Society. "Principles of Analgesic Use in the Treatment of Acute Pain and Cancer Pain." Glenview, IL: American Pain Society. 2003.…
INDEX 1.Introduction to Clinical Trials 3 2.Clinical Trial Protocol 5 3.International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use 6 1.1.Introduction to GCP 6 1.2.Sections of GCP Guidelines 6 3.2.1.1Section 1- Glossary of various terms 6 3.2.1.2Section 2- Principles of ICH-GCP 7 3.2.1.3Section 3- Institutional Review Board/Independent Ethics Committee(IRB/IEC) 8 3.2.1.4Responsibilities 8 3.2.1.5Composition, Functions and Operations 8 3.2.1.6Procedures 8 3.2.1.7Records 8 3.2.1.8Section 4- Investigator 9…
and its potential benefits could be utilized by the patients in the management of pain…
It is generally prescribed for patients who cannot go with the general flow or the conventional diets and supplements do not help in reducing chronic and inflammatory pain. Activation of the sympathetic nervous system promotes pro-inflammatory cytokines while…
Aspirin is in a class of medications called salicylates. Common adverse effects include: gastrointestinal (GI) distress (including upset stomach, heartburn, nausea, vomiting). Less common severe adverse effects include: tinnitus, Reye syndrome, GI ulceration, allergic reactions (including hives, shortness of breath, swelling, and/or anaphylaxis.)…
Gastrointestinal side effects may include abdominal pain, black hairy tongue, colitis, diarrhea, generalized abdominal cramps, hemorrhagic colitis, nausea, pseudomembranous colitis (Clostridium difficile associated diarrhea), and vomiting. Renal side effects may include acute interstitial nephritis and crystalluria, which is frequently associated with eosinophilia, fever, and rash. Nervous system side effects are rare but may include agitation, anxiety, behavioral changes, confusion, convulsions, dizziness, headache, insomnia, reversible hyperactivity, and somnolence.…
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This medication, the label states, may cause dizziness, light headedness, Vertigo, cramps, diarrhea, constipation, headaches, ear aches, Gingivitis, Gout, fainting spells, stomach pains, thoughts of suicide, and even death. For goodness sake, I’m only taking it for a headache, not preparing for cremation.…
• Citric, tartaric and malic acid • Lactone of hydroxycitric acid • Phenolics like anthocyanins involving the glycosides of delphinidin and cyanidin…
Tranexamic acid is a synthetic derivative of the amino acid lysine. It exerts its antifibrinolytic effect through the reversible blockade of lysine-binding sites on plasminogen molecules. Anti-fibrinolytic drug inhibits endometrial plasminogen activator and thus prevents fibrinolysis and the breakdown of blood clots. The plasminogen-plasmin enzyme system is known to cause coagulation defects through lytic activity on fibrinogen, fibrin and other clotting factors. By inhibiting the action of plasmin (finronolysin) the anti-fibrinolytic agents reduce excessive breakdown of fibrin and effect physiological hemostasis. |…