4. Observational studies have a significant role in CER for the reason that they can address issues that are otherwise difficult or impossible to …show more content…
Observational studies are useful for numerous of things. Observational studies are useful for examining multiple treatment paradigms simultaneously (Dreyer et al., 2010). Next, observational studies are best used to assess the real-world applicability of evidence derived largely through randomized trials (Dreyer et al., 2010). Also, observational studies can provide useful evidence when trails have not been or cannot be performed (Dreyer et al., 2010). Some examples are when it would be politically or ethically unacceptable to deny access to interventions, as in the case of vaccines in a face of a threat of an influenza pandemic (Dreyer et al., 2010). Moreover, observational studies can be useful when larger studies are needed to understand the real-world benefits of different dosing and routes of administering a drug (Dreyer et al., 2010). Observational studies can be useful when patients’ adherence to treatment differs, when providers have different training, and when treatments are off-label (Dreyer et al.,